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آناليز ژنوم جهت تعيين خصوصيات مقاومت به انگل ها در نشخوارکنندگان کوچک Coordinated Research Project on “Genetic Variation on the Control of Resistance to Infectious Diseases in Small Ruminants for Imp
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نام پروژه:
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دانشگاه تبريز- فائو- سايبرسدورف
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محل پروژه:
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2011
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سال:
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Coordinated Research Project on
“Genetic Variation on the Control of Resistance to Infectious Diseases in Small Ruminants for
Improving Animal Productivity”
The Coordinated Research Project (CRP) on “Genetic variation on the control of resistance to
infectious diseases in small ruminants for improving animal productivity” is part of the FAO/IAEA
Project 2.1.2.4 “Innovative nuclear based approaches to maintain biodiversity and enhance livestock
productivity”, that has the overall objective of improving productivity in smallholder animal systems
using gene based and related technologies.
Much of the genetic biodiversity controls advantageous traits influencing adaptability to harsh
environments, productivity, or disease resistance. However, indigenous animals are underutilized in
conventional breeding programmes, due to a lack of knowledge and failure to identify breeds and
animals carrying the most advantageous traits. There are indigenous breeds with some degree of
enhanced resistance as compared to exotic ones reared in the same environment, especially for
gastrointestinal nematode infections. Genetic disease resistance is particularly relevant in developing
countries, as indigenous breeds usually display enhanced resistance to local diseases as compared to
exotic ones reared in the same environment, but little is known on the genetic composition controlling
this condition.
The rapid and growing knowledge on genes and genomes in livestock such as the assessment of a
large number of DNA markers in phenotypic recorded populations could be used to localize and
further characterize candidate genes of economic interest. The analysis of mutations (SNPs) is in
essence the discovery and exploitation of the natural variation existing in the biological machinery
with the aim of increasing the frequency of favourable alleles to the benefit of livestock breeding
strategies.
The present CRP is aiming through genomic studies using radiolabeled nucleotides in DNA
hybridization, DNA characterization, and hybrid mapping procedures for identifying molecular
markers of economic interest which will open possibilities in the future to select and breed animals for
enhanced resistance to diseases. The CRP also targets to develop capacity in developing countries in
the use of molecular and related technologies and create opportunities for international research
collaboration. It was initiated in June 2010 with the award of 14 Research Contracts, 4 Research
Agreements, and one Technical Contract.
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چکیده طرح یا پروژه:
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